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Carbamazepine tegretol ; diet pills or cold medicines that contain ephedrine, pseudoephedrine, or phenylephrine; nafcillin unipen ; phenobarbital luminal, solfoton ; rifampin rifadin, rifater, rifamate, rimactane ; or an antidepressant such as amitriptyline elavil , amoxapine ascendin , bupropion wellbutrin, zyban , citalopram celexa , clomipramine anafranil , desipramine norpramin , doxepin sinequan , duloxetine cymbalta , escitalopram lexapro , fluoxetine prozac , fluvoxamine luvox , imipramine tofranil , nortriptyline pamelor , paroxetine paxil , protriptyline vivactil , sertraline zoloft , venlafaxine effexor , or trimipramine surmontil .
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recently, another antidepressant, bupropion-amfebutamone, was also shown to have a preventive therapeutic effect in a murine model of severe sepsis 10 .
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in vitro studies indicate that bupropion is primarily metabolized to hydroxybupropion by the cyp2b6 isoenzyme.
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48 venlafaxine may lower the seizure threshold, and coadministration with other drugs that lower the seizure threshold such as bupropion and tramadol should be done with caution and at low doses.
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bupropion works by blocking the re-uptake of a certain chemical substance in the brain called catecholamines.
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